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通过超声来服药 – 译学馆
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通过超声来服药

Ultrasound drug delivery

肠胃类疾病
Gastro intestinal based diseases
如炎症性肠病
such as inflammatory bowl
是一个很大的问题
disease are a huge problem
因为他们损害器官的
because them impair the organs’
本身功能并直接导致
function locally and cause
对组织的非常严重的
really severe inflammation of
炎症
the tissue directly.
所以,你需要得到对
And so, you need to get local
局部精准的药物治疗
concentrations of drug to that
来压制住该组织的
tissue to tamp down the
炎症,但是很多
inflammation but a lot of the
随着疾病出现的
symptoms that come along with
症状会阻碍
these diseases prevent being
这些药物留在局部
able to retain the drug locally
以至于无法充分吸收
to get sufficient absorption
来治疗炎症
to treat the inflammation.
所以,我们在这里
So, the problem that we’re
提出的问题是要确保
addressing here is ensuring
药物能够到达组织
the drug reaches the tissue,
以及确保尽快的
and insuring that happens as
起效,这样就能
fast as possible so that the
让药物发挥它的
drug can start exerting its
对疾病的治愈能力。
affect on the disease.
因此,当前的技术运用了
So the technology utilizes
超声波。大多数人
ultrasound and most people
熟悉超声波
are familiar with ultrasound
在医疗成像领域的应用
in the clinic for imaging,
例如,常见的是非常
for example, and that’s very
高频的超声波。这个设备
high-frequencies. This device
使用的是非常低频的声波
uses really low frequencies,
约低于100赫兹。
below about 100 kilohertz.
在这些频率会发生什么
What happens at those frequencies
当超声波传播吗
is when ultrasound is propagating
通过流体实际上
through a fluid it actually
成核小泡沫。
nucleates little bubbles.
这些泡沫移动
And these bubbles move around
混乱的搅拌
chaotically and they stir the
解决方案。最终他们
solution. Eventually they
其实内爆,
actually implode and that
创建的小飞机
creates little jets of the
周围的解决方案,和它的
surrounding solution, and its
当这些飞机撞到组织
when these jets hit the tissue
他们每种情况下能,
they’re able to, sort of,
推动的药物
physically push the drug into
组织,这就是你
the tissue, and thats how you
得到这个超快速交货
get this ultra-rapid delivery
和推动的药物
and pushing of the medication
组织,在本地。作为
into the tissue, locally. As
而不仅仅是等待
opposed to just waiting for the
药物缓慢,运输的
drug to slowly, sort of, transit
或扩散到组织。
or diffuse into the tissue.
这是一个活跃的形式
Here it is an active form of
交付。所以我们真的希望
delivery. So we really hope
这种技术可以让
this technology can make it to
我们的诊所可以使用
the clinic, be used by the
患者最需要它
patients who need it the most
改善临床结果
to improve clinical outcomes
和提高真正的质量
and improve really the quality
他们的生活
of life they they’re able
生活。
to live.

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