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如何知道一个胚胎能否存活? – 译学馆
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如何知道一个胚胎能否存活?

In the Race for Life, Which Human Embryos Make It? | Deep Look

这是受精一天后的人类胚胎
What you’re seeing here is a human embryo, about one day after fertilization.
我们都是这么来的
Every one of us started out this way,
从一个细胞分裂成两个 三个 很多个细胞
as a single cell dividing into two cells, then three, four,
而一个胚胎能否长成婴儿
and more. But it takes nature a lot of trial and error
是通过试错法决定的
to go from this… to this.
只有大约三分之一的胚胎
Only a few embryos, about one in three,
有足够良好的基因构造
have a genetic makeup that’s good enough
能长成婴儿
to let them to grow into a baby.
这现象的原因未知
Scientists don’t know why,
而这使得人类的繁衍率 相较于其他哺乳动物 非常低下
but we humans are some of the least fertile mammals around.
不久前 斯坦福大学的科学家们
Not long ago, when Stanford University scientists
从人类胚胎的慢速生长视频中
made this time-lapse video of developing embryos,
得到了新的发现
they noticed something no one had ever seen before.
在那之前 研究员认为
Up til then, researchers thought that embryos
胚胎可以以不同速率生长 并且仍然保持健康
could grow at many different rates and still be healthy.
但他们发现可存活的胚胎的成长
But they discovered that viable embryos actually follow a pattern,
都遵循了精确的“胚胎时钟”
a precise embryonic clock.
这对于接受体外受精的患者意义重大
This has huge implications for patients going through in vitro fertilization,
一个个在实验室里为他们悉心培养的胚胎
for whom each embryo, carefully cultivated in the lab
在植入女性体内之前 都是他们希望的寄托
before it’s transferred into a woman, is an embodiment of hope.
对于像劳拉和亚历克斯·依斑娜这样的患者
For patients like Laura and Alex Ibanez
他们关心的是 到底哪一个胚胎能健康长大
the question is: Which of their embryos can become a baby?
这风险很高 植入太多健康的胚胎
The stakes are high: transfer too many healthy embryos
可能会导致危险的双胎或三胎妊娠
and you could end up with a risky twin or triplet pregnancy.
而植入太少则可能受孕失败
Transfer too few and patients might not have a baby at all.
如果胚胎学家的预测能更准确情况就会不同
So what if embryologists could make more accurate predictions?
门罗帕克的一个公司致力于实现这个想法
A company in Menlo Park wants to make that possible.
他们把胚胎在恒温箱里的成长过程录下来
They film the embryos with a tiny camera inside the incubator.
电脑的计算程序会自动跟踪
A computer algorithm automatically tracks
每个胚胎的成长过程
the development of each embryo.
新的圆圈代表新的细胞分裂
A new ring means the computer has picked up on a new cell division.
一个能在9到11小时内 从2个细胞分裂成3个
Embryos that go from two to three cells in 9 to 11 hours,
在之后2小时内 再分裂成4个细胞的胚胎
and then from three to four cells in under two hours
最有可能存活到关键的第五天
have the best chance of making it to day five – a critical milestone.
因为在第五天 胚囊会突破透明带
Because on Day 5, the embryo gets ready to break out of its shell
准备在子宫腔内着床
and attach to the uterus.
FDA去年批准了这项测试
This test was cleared by the FDA last year.
如今已被超过30个诊所运用
Today it’s in more than 30 clinics.
我们常说生命是奇迹
You often hear life described as a miracle.
更奇妙的是 我们如今
And it seems even more wondrous, now that we’ve coaxed nature
能探索自然的奥秘
into revealing some of its secrets,
窥见生命的起源
to give us a glimpse into how it all begins.

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视频概述

是什么决定人类受精卵能否安全着床,长成婴儿?

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翻译译者

晨曦

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审核团Z

视频来源

https://www.youtube.com/watch?v=9mv_kuwQvoc

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