Hey, everyone, thank you for coming back to DNews Plus again.
Today for the final episode, episode three of three on puberty.
So so far we’ve talked about how humans go through puberty,
why we don’t just come out from our mom’s ready to breed other than,
you know, the awkward social situations that would cause.
We’ve also talked about animals going through puberty
and what exactly is going on in your brain and in your body
when puberty is happening.
But what about once puberty has happened,
can you ever go back to pre-puberty?
Can you reverse it?
That’s what we’re gonna talk about today.
So let me put the kibosh on reversing puberty kind of out of the gate.
Yes, it can happen.
However, in a healthy person
in your brain puberty essentially lasts forever
Once your glands start making these hormones
and squirting them all over your body,
it doesn’t stop, they continue doing that.
Yes the levels will change,
yes certain things about your body will change,
but once you’ve gone through puberty,
it just keeps making those hormones.
You know, some things though
never go away for some people,
acne never goes away for some people,
the hormones don’t go away for a lot of people,
and the brain, it just keeps telling you, you’re a sexually mature adult.
Once that happens, that Bieber concert just goes for the rest of your life, man!
There is such thing though as puberty being reversed,
it can happen to you.
But it’s not really naturally.
For example, a snake bite can cause puberty to reverse itself.
A Russell Viper aka Russell’s pit viper is venomous.
PS: 不是有毒的 而是分泌毒液的
Sidebar, it’s not poisonous, it’s venomous.
Venomous means they’re attacking you and injecting you with venom,
poisonous is like I ate a poisonous apple,
because I’m Snow White in this scenario.
再PS: 你摄入毒物 毒液是则是被注入你体内
You ingest poison, venom is injected into you and sidebar,
so near, Russell’s pit vipers.
They’re from Southeast Asia, they normally eat rodents,
and if it bites a human, the venom will get to your kidneys
and destroy them, often causing kidney failure,
and that’s what would kill you.
But if you survive all of the hemorrhaging and the kidney damage,
you can reverse your puberty.
The Lancet published a story where 29% of patients
who survived the Russell’s pit viper venom
had signs of something called hypopituitarism.
记得吧 之前讲过的 脑下腺
Remember, old friend, pituitary gland,
a guy, rockstar, the Biebs.
If it’s damaged,
it’s gonna stop making those hormones, and if it stops making those hormones,
then you stop looking like you pubertied.
Hypopituitarism is quote “diminished hormone secretion by the pituitary gland,
causing dwarfism in children and premature aging in adults”.
People who experience hypopituitarism lose fertility.
They lose sex drive, they lose body hair,
they lose pubic hair, men lose facial hair and muscle mass,
and women lose curves,
and they lose weight in general.
It kind of made me think when I was reading about this,
that puberty is sort of a mask that we all wear. Right?
Once you go through development, your body makes these changes,
but they can be undone.
You can be stripped of your puberty, sort of.
There is also a syndrome called Sheehan’s Syndrome,
which is also based on damage to the pituitary gland.
It causes thyroid problems, adrenal problems,
breast milk production problems and menstrual function dysfunctions.
The Mayo Clinic says that people who have Sheehan’s Syndrome
will have difficulty breastfeeding or will be unable to breastfeed.
They’ll have no menstrual periods or infrequent menstruation;
they’ll lose their pubic and underarm hair;
they could have low blood pressure, fatigue, irregular heartbeat;
they’ll have loss of interest in sexual activity, slowed mental function,
weight gain and difficulty staying warm
as a result of an underactive thyroid.
The difference between Sheahan’s Syndrome and being bitten by a Russell’s pit viper
is that Sheehan’s Syndrome happens usually because of
oxygen deprivation or severe blood loss during childbirth,
the pituitary gets damaged, somehow.
And it can also happen from low blood pressure and any number of different things,
usually again though during childbirth,
and its more common in developing nations so
So it’s still out there and it’s still can happen
and it’s not so much reversing puberty as keeping it from happening in children.
However some of the studies I read
said that once you were bit by a pit viper, you can develop Sheehan’s Syndrome.
Also if your pituitary is somehow damaged as an adult and stops making these hormones
that are keeping you pubertied,
you would end up getting Sheahan’s Syndrome.
Super interesting, right?
The thing is we could cure it,
因为 记着 这些只是激素
because remember, these are just hormones.
They’re just hormones and we know what they are and
we know what they do and we know where they come from.
So if the pituitary gland is damaged,
hormone replacement therapy can rescue you
and literally replace the missing hormones.
For the rest of your life,
you’d have to be taking those or you would again revert back to a pre-pubescent state,
but it’s possible.
And it sort of gives you a whole new perspective
on this very talked-about group of humanity right now,
transgender people, right?
Because essentially what they’re doing is hormone replacement therapy
in order to be the gender that they identify with.
And doctors are just providing androgens for those transitioning to male
and estrogens for those transitioning to female.
If you have Sheehan’s Syndrome, you’re doing the same thing.
You’re given people androgens or estrogens and other hormones,
so that you have a sex drive, so that you grow hair in funny places,
start liking girls or boys or whatever.
Another way that puberty gets messed with is that it’s starting way earlier.
We briefly touched on this earlier on,
but breast development a generation ago,
started at around 11 years old with girls.
Now it’s coming in around 7 years old and if it comes in really early,
it’s called precocious puberty and that can happen as early as the age of 3,
though that’s very very rare.
不同的种族 人种 社会经济条件
Different racial groups, different ethnic groups, different socio-economic groups
all have different effects on this.
It’s a very complicated topic, but precocious puberty is
becoming more common in some groups,
and many think that a factor for puberty starting early is obesity.
This could be, because
obesity has more than doubled in children since 1980s
and could cause puberty to start early,
because fat cells manufacture a hormone
that you’ve heard about already
called Gonadotropin-releasing hormone or GnRH.
Fat cells make it.
The hormone is usually made by the hypothalamus to induce puberty,
but now it’s being made by something else in the body, potentially causing puberty to start sooner.
But there may be other factors as well,
obviously more research is needed
and they’re doing that research now.
We’ve talked about it a little bit over on the other show
that we do Dnews as opposed to Dnews plus
I’m assuming that you already watch that show.
如果你没有 请检查一下 订阅它
If you don’t, check it out please, give it a subscribe.
The thing that I really want to know though, kind of goes all the way back to the beginning.
And that is why does brain development take so long,
why does it take so long to get in there
and start making hormones, right?
So even though I just said puberty is like a mask that you wear,
that’s more the physical aspects of puberty.
Remember we’ve already talked about
how the physicality is not the same as what’s going on in the brain,
hormones start to flood the brain during puberty
and even if you take those away,
the brain is changed forever by those,
even though the body can be reversed, the brain is set.
在06年的一项研究中 他们使用了FMRI扫描 即功能性核磁共振
In a 2006 study, they used fMRI scans which are functional MRIs,
they followed blood around the brain, and they scanned 9 year olds and 11 year olds,
compared their brains to see what puberty was changing,
what structures behaved differently, or needed more or less blood,
is really what happened.
According to them, at 9 years old,
the dorsal-lateral prefrontal cortex had more activity.
There is proliferation of synapses at the onset of puberty,
which means more and more synapses were being made by the brain,
connections between brain cells
Elimination and reorganization of synaptic connections after puberty
resulted in a gradual decrease in synaptic density
in the frontal lobes during adolescence,or to translate as the synapse
is connected at the beginning, some of those were trimmed away,
and that synaptic pruning as it’s called
was to make sure that the brain was working efficiently.
So when puberty starts, your brain makes all sorts of connections all over the place,
and then it starts to trim back the ones that you’re not using.
The gray matter that we were talking about earlier on reflects
that’s synaptic reorganization they think.
There’s also a steady increase in white matter in certain brain regions during adolescence.
大致上 灰质负责思考 白质负责传导
Grey matter by the way is like think matter, white matter is like speedy matter,
makes your brain faster.
So steady increase in white matter in certain brain regions during adolescence was noted,
which means your brain is working faster that comes back to you,
you having more executive function and starting to process things like an adult.
Executive function has shown to plateau in performance
between late childhood and early adolescence,
so at some point, you reach your potential,
and you are now at your level of executive function for adulthood.
Super interesting stuff, but all of that is permanent.
You know there is some things that change throughout your life in your brain,
but once the hormones have kicked that into gear,
it’s not gonna take that stuff away.
Changing brain synapses is very difficult,
takes lots of time and practice, you know.
Our brains are very plastic, but it’s not just gonna suddenly wipe clean a bunch of synapses.
On top of that, things like bone density and thickening,
the lower voice that you get by the lengthening and changing of your vocal cords, breast growth,
those things are not gonna go away if you take hormones away.
You can’t ungrown broad shoulders or a growth spurt,
you can’t ungrown breasts.
It’s not gonna happen.
Puberty is a natural part of growing older.
It’s really the point where the human body says:
“What up, let’s mate.”
That’s what it’s for.
That’s the point biologically, societally and culturally
and as a species, that’s not always the best plan.
Once it starts, you know,
at age six or eleven or nine or fifteen, whenever it does finally start,
that doesn’t necessarily mean now is the time to mate,
societally and culturally, right?
It all depends, but knowing how this sticky machine all works,
super interesting, pretty damn cool.
If you want to learn more about health stuff,
你可以查阅Sex Sent Me to the ER
you should check out Sex Sent Me to the ER.
I know that sounds weird. It’s an awesome show,
你也可以在Discovery Life Go这个软件上
and you can also find that and other discovery shows
on the Discovery Life Go app,
there’s a link in the description, you can check it out.
我当然看过Sex Sent Me to the ER 没什么好害羞的
I’ve definitely watched Sex Sent Me to the ER, not ashamed.
It’s really good and weird.
Thanks for watching everybody, we’ll see you next time on DNews Plus.