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找到癌症的死对头

Finding a Cancer Killer | Breakthrough

讲述者:任教于宾夕法尼亚大学的
NARRATOR: Working out of the University of Pennsylvania,
琼恩博士一直在研发一种新技术
Dr. June has been developing a new technology
借助免疫系统的T细胞抵御
to leverage the immune system’s T-cells to fight
并消灭老鼠体内的血癌细胞
and kill leukemia in mice.
[吱吱声]
[squeaking]
卡尔·琼恩:是的
CARL JUNE: Yeah.
这是一个漫长的过程
I have been through a long journey.
所以我算是一个内科医生
So I was a physician.
渐渐的 我得出一个结论
And then gradually, I came to the conclusion
或许我的科学实验成果
that I could probably help more people
能够帮到更多的人
through my scientific laboratory efforts
而不是眼睁睁看着他们一个又一个躺在诊所里却无能为力
than actually seeing people one at a time in a clinic.
我告诉我的家人 现在我成了老鼠博士
And I tell my family now that my MD stands for mouse doctor.
讲述者:免疫系统能够
NARRATOR:The immune system protects
使你免遭外部病菌的入侵
you from outside invasion.
若病毒 细菌或真菌悄然进入你的身体
If a virus, bacteria, or fungus slips into your body,
免疫系统便会发起协同攻击
the immune system responds with a coordinated attack that
杀死侵略者 而不会破坏其他细胞
kills the invader, and only the invader,
你的身体才会完好无损
leaving your body intact.
[咯咯]
[chittering]
这是T细胞
This is a T-cell.
它的工作就是提前消灭感染细胞
This immune cell’s job is to kill infected cells
防止其造成更大的损伤
before they cause more damage.
理论上 T细胞可以非常有效地
In theory, T-cells can be extraordinarily
抵御血癌细胞
potent against leukemia.
但问题是
But there’s one problem.
癌细胞其实也属于身体的一部分
Since cancer is effectively part of your own body,
免疫系统有时会忽略它们
the immune system sometimes ignores
使癌细胞继续泛滥成灾
these rogue cells, allowing the cancer to spread unchecked.
琼恩博士和他的团队废寝忘食地工作
June and his team have worked tirelessly
希望找到能够让免疫系统识别并摧毁
to find a way to get the immune system
身体中所有癌细胞的方法
to recognize and destroy all of the cancer cells in the body.
琼恩·卡尔:我们正在研究的治疗方法
CARL JUNE: The therapy we’re developing
是多个学科相融合的
is multidisciplinary.
我们团队中有白血病专家
It involves leukemia specialists.
大卫·波特以治疗各种白血病
David Porter is known around the world
闻名世界
for his treating various kinds of leukemia.
这还涉及到免疫学鉴定 病毒载体结构鉴定
It involves immunology expertise, viral vector design
和细胞学鉴定 在这方面
expertise, and then the cell culture expertise that Bruce
我确信没有人比布鲁斯·列文
Levine knows more about than anyone in the world,
更专业
I’m quite sure.

OK.
而我是恶性肿瘤基因治疗专家
I’m a professor in cancer gene therapy.
指导他们进行临床细胞和
And I direct the Clinical Cell and Vaccine
疫苗生产
Production Facility.
我们研发 生产 测试
And what we do is to develop, manufacture, and test
细胞和基因疗法 用患者自身的免疫细胞抵御癌细胞
cell and gene therapies to fight cancer using the patient’s
靶向治疗癌症
own immune cells that have been genetically targeted to cancer.
[嗡嗡]
[humming]
CAR-T细胞是经过基因改良后的T细胞
A CAR-T cell is a T-cell that is genetically
它可以发现
modified in a way that allows it to see
并识别癌细胞
and recognize a cancer cell.
CAR代表嵌合抗原受体
A “CAR” stands for chimeric antigen receptor.
它是合成分子
It’s a molecule that is synthetic.
我们把它和免疫细胞结合
We can put it into an immune cell
改良免疫细胞的基因
and genetically change the immune cell
使CAR分子得以表达
to express the CAR molecule.
二者结合不但激活了T细胞
That function of binding activates the T-cell.
还使CAR分子更加活跃
And it allows it to become active,
变成细胞杀手 消灭血癌细胞
to become a killer cell, and to kill the leukemia.
[嘣——]
[explosions]
[呀啊——]
[yelp]
[嗝——]
[belch]
[嘣——]
[explosion]

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视频概述

美国宾夕法尼亚大学的研究团队为癌症患者带来了福音,快来看!

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翻译译者

心随风飞

审核员

Ah~Qiu

视频来源

https://www.youtube.com/watch?v=D_gQCjxyVec

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